Article
The nature and nurture of cell heterogeneity: accounting for macrophage gene-environment interactions with single-cell RNA-Seq.
BMC genomics - 7 Jan 2017
Wills Quin F, Mellado-Gomez Esther, Nolan Rory, Warner Damien, Sharma Eshita, Broxholme John, Wright Benjamin, Lockstone Helen, James William, Lynch Mark, Gonzales Michael, West Jay, Leyrat Anne, Padilla-Parra Sergi, Filippi Sarah, Holmes Chris, Moore Michael D, Bowden Rory
Abstract excerpt
BACKGROUND: Single-cell RNA-Seq can be a valuable and unbiased tool to dissect cellular heterogeneity, despite the transcriptome's limitations in describing higher functional phenotypes and protein events. Perhaps the most important shortfall with transcriptomic 'snapshots' of cell populations is that they risk being descriptive, only cataloging heterogeneity at one point in time, and without microenvironmental...
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