Article

CIP2A promotes osteoclastogenesis and postmenopausal bone loss by activating a novel HMGA1–c-Myc–PI3K/AKT axis

2026-08-20

Abstract excerpt

<title>Abstract</title> <p>Background Osteoclast-mediated bone resorption drives osteoporosis, a prevalent skeletal disorder with significant clinical and socioeconomic burden, yet the upstream molecular mechanisms controlling osteoclast differentiation remain incompletely defined. Cancerous inhibitor of protein phosphatase 2A (CIP2A) is a known oncogenic regulator, but its role in bone metabolism and osteoclast...

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Literature Corpus work: 3cc238b1-bc50-50c1-b512-7eb1fc34cc55
DOI: 10.21203/rs.3.rs-9848947/v1

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