Article

High-fat diet promotes Acute Promyelocytic Leukemia through PPARδ-enhanced self-renewal of preleukemic progenitors

2022-03-16

Abstract excerpt

Obesity is associated with a higher risk of developing many cancer types including acute promyelocytic leukaemia (APL), a subset of acute myeloid leukemias (AML) characterized by expression of the PML-RARα oncogene. The molecular mechanisms linking obesity and APL development are not known. To model clinical observations, we established a mouse model of diet-induced obesity using transgenic mice constitutively exp...

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Literature Corpus work: 3cbbeba2-3f29-56b6-badf-55f98345abb9
DOI: 10.1101/2022.03.14.483944

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High-fat diet promotes Acute Promyelocytic Leukemia through PPARδ-enhanced self-renewal of preleukemic progenitorsDOI 10.1101/2022.03.14.483944Read

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