Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeting GLP-1R and IL-17A suppresses obesity-induced leukemia in an oncogenic PTPN11 mutation-driven model.

The Journal of clinical investigation - 3 Aug 2026

Kapur Reuben, Li Linke, Kanumuri Rahul, Padam Kanaka Sai Ram, Ramdas Baskar, Pasala Chiranjeevi, Chiosis Gabriela, Palam Lakshmi Reddy, Kumar Ramesh, Koyama Satoshi, Natarajan Pradeep, Haneline Laura S, Yu Zhi, Pasupuleti Santhosh Kumar

Abstract excerpt

Obesity is increasingly implicated in hematopoietic malignancies, yet its role in mutation-driven myeloid leukemias remains unclear. Using UK Biobank data from over 440,000 individuals, we found obesity traits including elevated BMI and waist-to-hip ratio were associated with type 2 diabetes, increased plasma IL-17A levels, reduced glucagon-like peptide 1 receptor (GLP-1R) expression, and heightened risk of...

Topics

Join the communities discussing this publication.

Glucagon-Like Peptide-1 Receptor
Interleukin-17
Leukemia, Myeloid
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Proteins

Protein Tyrosine Phosphatase, Non-Receptor Type 11

Source

Open in PubMed Open full text

Identifiers

PMID: 42334870
DOI: 10.1172/JCI202856
PMCID: PMC13430024

Genes

PTPN11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeting GLP-1R and IL-17A suppresses obesity-induced leukemia in an oncogenic PTPN11 mutation-driven model.PMID 42334870Read ↗

The impact of obesity-induced inflammation on clonal hematopoiesisSemantic proximity Read ↗

Exploring the impact of body mass index on tumor biology and cancer developmentSemantic proximity Read ↗

Dynamic remodeling of the pancreas immune landscape in obesitySemantic proximity Read ↗

Dynamic remodeling of the pancreas immune landscape in obesitySemantic proximity Read ↗

Body mass index-associated molecular characteristics involved in tumor immune and metabolic pathwaysSemantic proximity Read ↗

Unveiling the Genetic and Clinical Differences of Acute Myeloid Leukemia (AML) in Obese Patients.Semantic proximity Read ↗

Adipose tissue macrophages: implications for obesity-associated cancerSemantic proximity Read ↗

PPARɣ drives IL-33-dependent ILC2 pro-tumoral functionsSemantic proximity Read ↗

The intricate role of adipokines in cancer-related signaling and the tumor microenvironment: Insights for future researchSemantic proximity Read ↗

Morbidly obese human subjects have increased peripheral blood CD4+ T cells with skewing toward a Treg- and Th2-dominated phenotype.Semantic proximity Read ↗

Is There a Causal Relationship between Childhood Obesity and Acute Lymphoblastic Leukemia? A ReviewSemantic proximity Read ↗

S1PR1/S1PR3-YAP signaling and S1P-ALOX15 signaling contribute to an aggressive behavior in obesity-lymphomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.