Article

Structure-based Generation of a Secondary Nucleation Inhibitor in α-Synuclein Aggregation Using a Conditional Diffusion Model

2025-08-17

Abstract excerpt

The process of α -synuclein aggregation results in the formation of amyloid fibrils, which accumulate in the brain of patients affected by Parkinson’s disease. Among possible therapeutic strategies to cure this disease, one approach is based on the development of compounds capable of inhibiting α -synuclein aggregation. An effective inhibition could be achieved by blocking the nucleation sites on the surface of...

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Literature Corpus work: bf3ed79f-4936-5f36-b42b-0f0c35aa1af1
DOI: 10.1101/2025.08.16.670694

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