Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

In Vivo Validation of a Small Molecule Inhibitor of Tau Self-Association in htau Mice.

Journal of Alzheimer's disease : JAD - 1 Jan 2020

Davidowitz Eliot J, Krishnamurthy Pavan K, Lopez Patricia, Jimenez Heidy, Adrien Leslie, Davies Peter, Moe James G

Abstract excerpt

Tau oligomers have been shown to transmit tau pathology from diseased neurons to healthy neurons through seeding, tau misfolding, and aggregation that is thought to play an influential role in the progression of Alzheimer's disease (AD) and related tauopathies. To develop a small molecule therapeutic for AD and related tauopathies, we have developed in vitro and cellular assays to select molecules inhibiting the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Brain Chemistry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dose-Response Relationship, Drug

Share to Hippocampus

Share to Sex Characteristics

Share to Small Molecule Libraries

Share to tau Proteins

Share to Tauopathies

Source

Open in PubMed Open full text

Identifiers

PMID: 31771053
DOI: 10.3233/JAD-190465
PMCID: PMC6957711

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

In Vivo Validation of a Small Molecule Inhibitor of Tau Self-Association in htau Mice.PMID 31771053Read ↗

Design of Tau Aggregation Inhibitors Using Iterative Machine Learning and a Polymorph-Specific Brain-Seeded Fibril Amplification AssaySemantic proximity Read ↗

Evaluating the efficacy of commercially available antisense oligonucleotides to reduce mouse and human tau <i>in vivo</i>Semantic proximity Read ↗

Discovery of Dual Aβ/Tau Inhibitors and Evaluation of Their Therapeutic Effect on a Drosophila Model of Alzheimer’s DiseaseSemantic proximity Read ↗

Peptide-based inhibitors of Tau aggregation as a potential therapeutic for Alzheimer’s disease and other TauopathiesSemantic proximity Read ↗

Functional Selection of Tau Oligomerization‐Inhibiting AptamersSemantic proximity Read ↗

Tau Disaggregation by a CNS-Permeable Small Molecule Reduces Fibril and Oligomer Burden and Preserves Proteostasis and BehaviorSemantic proximity Read ↗

Rescue from tau-induced neuronal dysfunction produces insoluble tau oligomers.Semantic proximity Read ↗

Highly specific and selective anti‐pS396‐tau antibody C10.2 targets seeding‐competent tauSemantic proximity Read ↗

Small-Molecule Amyloid Beta-Aggregation Inhibitors in Alzheimer's Disease Drug DevelopmentSemantic proximity Read ↗

Using Human iPSC-Derived Neurons to Model TAU Aggregation.Semantic proximity Read ↗

Major Differences between the Self-Assembly and Seeding Behavior of Heparin-Induced and in Vitro Phosphorylated Tau and Their Modulation by Potential InhibitorsSemantic proximity Read ↗

Discovery of compounds that will prevent tau pathology.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.