Article

Development and Optimization of A High-Throughput 3D Rat Purkinje Neuron Culture to Study Paraneoplastic Cerebellar Degeneration

2022-01-07

Abstract excerpt

<title>Abstract</title> <p>Improved understanding of the mechanisms involved in neurodegenerative disease has been hampered by the lack of robust cellular models that faithfully replicate <italic>in vivo</italic> features. Here, we present a refined protocol for generating age-dependent, well-developed and synaptically active rat Purkinje neurons in a 3D cell network culture which are responsive to a disease indu...

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Literature Corpus work: 3cb45d08-d119-5248-b8bf-6041fccf0aeb
DOI: 10.21203/rs.3.rs-1166640/v1

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