Article

Development and optimization of a high-throughput 3D rat Purkinje neuron culture

2020-05-22

Abstract excerpt

Improved understanding of the mechanisms involved in neurodegenerative disease has been hampered by the lack of robust cellular models that faithfully replicate in vivo features. Here, we present a refined protocol for generating age-dependent, well-developed and synaptically active rat Purkinje neurons, responsive to paracrine factors and supporting a 3D cell network. Our model provides high experimental flexibi...

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Literature Corpus work: a41f4b24-d273-5b72-a5e2-3f7e5383b763
DOI: 10.1101/2020.05.20.105858

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