Article
Closing the phenotypic gap between transformed neuronal cell lines in culture and untransformed neurons.
Journal of neuroscience methods - 15 Sept 2008
Myers Tereance A, Nickerson Cheryl A, Kaushal Deepak, Ott C Mark, Höner zu Bentrup Kerstin, Ramamurthy Rajee, Nelman-Gonzalez Mayra, Pierson Duane L, Philipp Mario T
Abstract excerpt
Studies of neuronal dysfunction in the central nervous system (CNS) are frequently limited by the failure of primary neurons to propagate in vitro. Neuronal cell lines can be substituted for primary cells but they often misrepresent normal conditions. We hypothesized that a three-dimensional (3D) cell culture system would drive the phenotype of transformed neurons closer to that of untransformed cells, as has...
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