Advancing Parkinson’s Disease Biopathlogy and Drug Discovery by Dual Cellular Modeling

Abstract excerpt

<title>Abstract</title> <p>Parkinson’s disease (PD) is the fastest growing neurological disorder in the world. Its pathologic hallmarks are dopaminergic neuronal loss in the substantia nigra and alpha-synuclein accumulation in neurons. However the patho-biologic mechanisms are largely unknown. Current drugs cannot slow or halt disease progression while clinical trials are mostly unsuccessful. Hence better cellula...

Topics

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• alpha-Synuclein
• Cell Line
• Disease Models, Animal
• Drug Evaluation, Preclinical
• Nanoparticles: synthesis and applications
• Parkinson Disease
• Parkinson's Disease Mechanisms and Treatments
• Phenotype

Identifiers and source

Literature Corpus work

b65d3601-b962-52fc-9bd1-9a538039258a

DOI

10.21203/rs.3.rs-5483934/v1