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Article

Deficiencies in germline DNA repair are associated with early-onset gastrointestinal cancers and inform precision prevention strategies.

Journal of translational medicine - 24 Dec 2025

Yang Wenhui, Zhang Yanxiang, Ge Minghui, Liu Luyao, Shu Yongqian, Shen Dong, Zhang Qin, Chen Dongsheng, Ping Xiaochun, Liu Yiqian

Abstract excerpt

BACKGROUND: Gastrointestinal (GI) cancers impose a significant global health burden and germline gene alterations play a significant role in the malignant transformation of epithelial cells. However, the prevalence and clinical relevance of pathogenic germline variations (PGVs) in Asian populations remain incompletely characterized. METHODS: This multicenter study analyzed six GI cancer types across 9470 Chinese...

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Identifiers

PMID: 41444968
DOI: 10.1186/s12967-025-07595-9
PMCID: PMC12903488

Genes

PC
GC
PIK3CA
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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