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Article

Germline Variants in DNA Interstrand-Cross Link Repair Genes May Contribute to Increased Susceptibility for Serrated Polyposis Syndrome.

International journal of molecular sciences - 4 Nov 2024

Silva Patrícia, Francisco Inês, Filipe Bruno, Lage Pedro, Rosa Isadora, Fernandes Sofia, Fonseca Ricardo, Rodrigues Paula, Parreira Joana, Claro Isabel, Albuquerque Cristina

Abstract excerpt

Serrated polyposis syndrome (SPS) is characterized by the development of multiple colorectal serrated polyps and increased predisposition to colorectal cancer (CRC). However, the molecular basis of SPS, especially in cases presenting family history of SPS and/or polyps and/or CRC in first-degree relatives (SPS-FHP/CRC), is still poorly understood. In a previous study, we proposed the existence of two molecular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39519399
DOI: 10.3390/ijms252111848
PMCID: PMC11546920

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