Article

The proteasomal deubiquitinating enzyme PSMD14 regulates macroautophagy by controlling Golgi-to-ER retrograde transport

2020-01-30

Abstract excerpt

<h4>ABSTRACT</h4> Ubiquitination regulates several biological processes. Here, we search for ubiquitin-related genes implicated in protein membrane trafficking performing a High-Content siRNA Screening including 1,187 genes of the human “ubiquitinome” using Amyloid Precursor Protein (APP) as a reporter. We identified the deubiquitinating enzyme PSMD14, a subunit of the 19S regulatory particle of the proteasome, s...

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Literature Corpus work: 3c9dd5de-01c4-50e4-a257-43278e843844
DOI: 10.1101/2020.01.29.925503

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