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Histology and spatial transcriptomic integration revealed infiltration zone with specific cell composition as a prognostic hotspot in glioblastoma

2025-10-08

Abstract excerpt

<h4>Background</h4> Glioblastoma (GBM), the most aggressive primary brain tumor, has a median survival of approximately 15 months. Twenty percent of patients survive beyond three years, but known clinical factors like age, performance status, resection extent, and MGMT promoter methylation status do not fully explain the observed outcomes. <h4>Objective</h4> Our objective was to identify novel histology derived...

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Literature Corpus work
b64dd966-b673-5ef7-a1c1-9057bddd08b3
DOI
10.1101/2025.10.08.681087
Open publication

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Histology and spatial transcriptomic integration revealed infiltration zone with specific cell composition as a prognostic hotspot in glioblastomaDOI 10.1101/2025.10.08.681087
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