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Article

Mre11 assembles linear DNA fragments into DNA damage signaling complexes.

PLoS biology - 1 May 2004

Costanzo Vincenzo, Paull Tanya, Gottesman Max, Gautier Jean

Abstract excerpt

Mre11/Rad50/Nbs1 complex (MRN) is essential to suppress the generation of double-strand breaks (DSBs) during DNA replication. MRN also plays a role in the response to DSBs created by DNA damage. Hypomorphic mutations in Mre11 (which causes an ataxia-telangiectasia-like disease [ATLD]) and mutations in the ataxia-telangiectasia-mutated (ATM) gene lead to defects in handling damaged DNA and to similar clinical and...

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Source

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Identifiers

PMID: 15138496
DOI: 10.1371/journal.pbio.0020110
PMCID: PMC406388

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mre11 assembles linear DNA fragments into DNA damage signaling complexes.PMID 15138496Read ↗

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