Article
Detection of complex genetic architecture using two-locus population differentiation: modeling epistasis
2020-07-01
Abstract excerpt
Recent advances in genetics have increased our understanding of epistasis as important in the genetics of complex phenotypes. However, current analytical methods often cannot detect epistasis, given the multiple testing burden. To address this, we extended our previous method, Evolutionary Triangulation (ET), that uses differences among populations in both disease prevalence and allele frequencies to filter SNPs f...
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Identifiers and source
- Literature Corpus work
- 3c744bbf-79b5-57e0-9b69-b576a04121c8
- DOI
- 10.1101/2020.07.01.182840