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Article

A novel evolution-based method for detecting gene-gene interactions.

PloS one - 1 Jan 2011

Rao Shaoqi, Yuan Manqiong, Zuo Xiaoyu, Su Weiyang, Zhang Fan, Huang Ke, Lin Meihua, Ding Yuanlin

Abstract excerpt

BACKGROUND: The rapid advance in large-scale SNP-chip technologies offers us great opportunities in elucidating the genetic basis of complex diseases. Methods for large-scale interactions analysis have been under development from several sources. Due to several difficult issues (e.g., sparseness of data in high dimensions and low replication or validation rate), development of fast, powerful and robust methods...

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Identifiers

PMID: 22046286
DOI: 10.1371/journal.pone.0026435
PMCID: PMC3201950

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