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Article

Accounting for diverse evolutionary forces reveals mosaic patterns of selection on human preterm birth loci.

Nature communications - 24 Jul 2020

LaBella Abigail L, Abraham Abin, Pichkar Yakov, Fong Sarah L, Zhang Ge, Muglia Louis J, Abbot Patrick, Rokas Antonis, Capra John A

Abstract excerpt

Currently, there is no comprehensive framework to evaluate the evolutionary forces acting on genomic regions associated with human complex traits and contextualize the relationship between evolution and molecular function. Here, we develop an approach to test for signatures of diverse evolutionary forces on trait-associated genomic regions. We apply our method to regions associated with spontaneous preterm birth...

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Identifiers

PMID: 32709900
DOI: 10.1038/s41467-020-17258-6
PMCID: PMC7382462

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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