Article
Evolutionary dynamics of co-segregating gene clusters associated with complex diseases.
PloS one - 1 Jan 2012
Preuss Christoph, Riemenschneider Mona, Wiedmann David, Stoll Monika
Abstract excerpt
BACKGROUND: The distribution of human disease-associated mutations is not random across the human genome. Despite the fact that natural selection continually removes disease-associated mutations, an enrichment of these variants can be observed in regions of low recombination. There are a number of mechanisms by which such a clustering could occur, including genetic perturbations or demographic effects within...
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