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Microbiota promotes systemic T-cell survival through suppression of an apoptotic factor

9 May 2017

Abstract excerpt

Symbiotic microbes impact the severity of a variety of diseases through regulation of T-cell development. However, little is known regarding the molecular mechanisms by which this is accomplished. Here we report that a secreted factor, Erdr1, is regulated by the microbiota to control T-cell apoptosis. Erdr1 expression was identified by transcriptome analysis to be elevated in splenic T cells from germfree and...

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PMID: 28487480
DOI: 10.1073/pnas.1619336114

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