Article
CHK2-FOXK axis promotes transcriptional control of autophagy programs.
Science advances - 1 Jan 2020
Chen Yuping, Wu Jinhuan, Liang Guang, Geng Guohe, Zhao Fei, Yin Ping, Nowsheen Somaira, Wu Chengming, Li Yunhui, Li Lei, Kim Wootae, Zhou Qin, Huang Jinzhou, Liu Jiaqi, Zhang Chao, Guo Guijie, Deng Min, Tu Xinyi, Gao Xiumei, Liu Zhongmin, Chen Yihan, Lou Zhenkun, Luo Kuntian, Yuan Jian
Abstract excerpt
Autophagy is an evolutionarily conserved catabolic process, which plays a vital role in removing misfolded proteins and clearing damaged organelles to maintain internal environment homeostasis. Here, we uncovered the checkpoint kinase 2 (CHK2)-FOXK (FOXK1 and FOXK2) axis playing an important role in DNA damage-mediated autophagy at the transcriptional regulation layer. Mechanistically, following DNA damage, CHK2...
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