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Article

Systems analysis of de novo mutations in congenital heart diseases identified a protein network in the hypoplastic left heart syndrome.

Cell systems - 16 Nov 2022

Wang Yuejun Jessie, Zhang Xicheng, Lam Chi Keung, Guo Hongchao, Wang Cheng, Zhang Sai, Wu Joseph C, Snyder Michael, Li Jingjing

Abstract excerpt

Despite a strong genetic component, only a few genes have been identified in congenital heart diseases (CHDs). We introduced systems analyses to uncover the hidden organization on biological networks of mutations in CHDs and leveraged network analysis to integrate the protein interactome, patient exomes, and single-cell transcriptomes of the developing heart. We identified a CHD network regulating heart...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36167075
DOI: 10.1016/j.cels.2022.09.001
PMCID: PMC9671831

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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