Article
Hypoxia and the metabolic phenotype of prostate cancer cells.
Biochimica et biophysica acta - 1 Dec 2009
Higgins L H, Withers H G, Garbens A, Love H D, Magnoni L, Hayward S W, Moyes C D
Abstract excerpt
Many cancer cells have an unusual ability to grow in hypoxia, but the origins of this metabolic phenotype remain unclear. We compared the metabolic phenotypes of three common prostate cancer cell models (LNCaP, DU145, PC3), assessing energy metabolism, metabolic gene expression, and the response to various culture contexts (in vitro and xenografts). LNCaP cells had a more oxidative phenotype than PC3 and DU145...
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