Article

ARHGAP18/SENEX enhances apoptosis resistance of B-cell non-Hodgkin lymphoma via inhibiting CDK4/6 to promote cellular senescence

2024-01-30

Abstract excerpt

<h4>Background: </h4> Resistance to existing therapies is currently the main reason for treatment failure in refractory/relapsed B-NHL patients, and therapy-induced senescence (TIS) is one of the important mechanisms of tumor drug resistance. <h4>Methods:</h4> Raji cells were transfected with the human SENEX shRNA recombinant lentiviral vector (Si-SENEX) and the empty vector negative (NC) to construct a stable tra...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3c152e11-b64b-5703-92f2-41048574d808
DOI: 10.22541/au.170663928.88822155/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

ARHGAP18/SENEX enhances apoptosis resistance of B-cell non-Hodgkin lymphoma via inhibiting CDK4/6 to promote cellular senescenceDOI 10.22541/au.170663928.88822155/v1Read

Transcriptomic signatures and network-based methods uncover new Senescent Cell Anti-Apoptotic Pathways and SenolyticsSemantic proximity Read

The cellular senescence of leukemia-initiating cells from acute lymphoblastic leukemia is postponed by β-Arrestin1 binding with P300-Sp1 to regulate hTERT transcriptionSemantic proximity Read

Sorafenib, rapamycin, and venetoclax attenuate doxorubicin-induced senescence and promote apoptosis in HCT116 cellsSemantic proximity Read

Novel senolytic and senescence-suppressing compounds overcome senescence-driven chemoresistance in NSCLCSemantic proximity Read

SENEBLOC, a long non-coding RNA suppresses senescence via p53-dependent and independent mechanismsSemantic proximity Read

SAPCD2 promotes neuroblastoma progression by altering the subcellular distribution of E2F7Semantic proximity Read

Applications and mechanisms of the cyclin-dependent kinase 4/6 inhibitor, PD-0332991, in solid tumorsSemantic proximity Read

CDC6, a key replication licensing factor, is overexpressed and confers poor prognosis in diffuse large B-cell lymphomaSemantic proximity Read

Expression and prognosis of cellular senescence genes in head and neck squamous cell carcinomaSemantic proximity Read

Expression of senescence-related CD161 promotes extranodal NK/T cell lymphoma by affecting T cell phenotype and cell cycle.Semantic proximity Read

SWI/SNF regulates a transcriptional program that induces senescence to prevent liver cancer.Semantic proximity Read

Induction of Cellular Senescence by Doxorubicin Is Associated with Upregulated miR-375 and Induction of Autophagy in K562 CellsSemantic proximity Read