Article

CDC6, a key replication licensing factor, is overexpressed and confers poor prognosis in diffuse large B-cell lymphoma

2022-09-22

Abstract excerpt

<h4>Background: </h4> Cell division cycle 6 (CDC6) is a key licensing factor in the assembly of pre-replicative complexes at origins of replication. The role of CDC6 in the pathogenesis of in diffuse larger B-cell lymphoma (DLBCL) remains unknown. We aim to investigate the effects of CDC6 on the proliferation, apoptosis and cell cycle regulation in DLBCL cells, delineate its underlying mechanism, and to correlate...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 73b84239-899d-55b9-975c-2f20a22a7e5a
DOI: 10.21203/rs.3.rs-2052017/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

CDC6, a key replication licensing factor, is overexpressed and confers poor prognosis in diffuse large B-cell lymphomaDOI 10.21203/rs.3.rs-2052017/v1Read

Cell Division Cycle-Associated Protein 8 in Pan-Cancer: A Comprehensive Prognostic and Immune Infiltration InvestigationSemantic proximity Read

The diagnostic and prognostic value of cell division cycle associated gene family in Hepatocellular CarcinomaSemantic proximity Read

CDCA8, a mitosis-related gene, as a prospective pan-cancer biomarker: implications for survival prognosis and oncogenic immunologySemantic proximity Read

MDM2-P53 Signaling Pathway-Mediated Upregulation of CDC20 Promotes Progression of Human Diffuse Large B-Cell LymphomaSemantic proximity Read

CDC6: from DNA replication to cell cycle checkpoints and oncogenesisSemantic proximity Read

A pan-cancer analysis reveals the diagnostic and prognostic role of CDCA2 in low-grade gliomaSemantic proximity Read

Cdc6 disruption leads to centrosome abnormalities and chromosome instability in pancreatic cancer cellsSemantic proximity Read

Roles of the CDCA gene family in breast carcinomaSemantic proximity Read

Analysis of CCND3 mutations in diffuse large B-cell lymphomaSemantic proximity Read

Systematic pan‑cancer analysis identifies CDC45 as having an oncogenic role in human cancersSemantic proximity Read

Inhibition of CDC20 suppresses the development and progression of mantle cell lymphoma through PI3K/AKT pathwaySemantic proximity Read

CDC20 in and out of mitosis: a prognostic factor and therapeutic target in hematological malignanciesSemantic proximity Read