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Article

SWI/SNF regulates a transcriptional program that induces senescence to prevent liver cancer.

Genes & development - 1 Oct 2016

Tordella Luca, Khan Sadaf, Hohmeyer Anja, Banito Ana, Klotz Sabrina, Raguz Selina, Martin Nadine, Dhamarlingam Gopuraja, Carroll Thomas, González Meljem José Mario, Deswal Sumit, Martínez-Barbera Juan Pedro, García-Escudero Ramón, Zuber Johannes, Zender Lars, Gil Jesús

Abstract excerpt

Oncogene-induced senescence (OIS) is a potent tumor suppressor mechanism. To identify senescence regulators relevant to cancer, we screened an shRNA library targeting genes deleted in hepatocellular carcinoma (HCC). Here, we describe how knockdown of the SWI/SNF component ARID1B prevents OIS and cooperates with RAS to induce liver tumors. ARID1B controls p16INK4a and p21CIP1a transcription but also regulates DNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27737960
DOI: 10.1101/gad.286112.116
PMCID: PMC5088567

Genes

ENTPD7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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