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SENEBLOC, a long non-coding RNA suppresses senescence via p53-dependent and independent mechanisms

21 Jan 2020

Abstract excerpt

Long non-coding RNAs (lncRNAs) have emerged as important biological tuners. Here, we reveal the role of an uncharacterized lncRNA we call SENEBLOC that is expressed by both normal and transformed cells under homeostatic conditions. SENEBLOC was shown to block the induction of cellular senescence through dual mechanisms that converge to repress the expression of p21. SENEBLOC facilitates the association of p53...

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PMID: 32030426
DOI: 10.1093/nar/gkaa063

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