Article

Single-cell transcriptomics reveals targeted modulation of inflammatory repertoire by SOCE blockers

2025-05-01

Abstract excerpt

<h4>ABSTRACT</h4> Store-operated calcium entry (SOCE) plays a critical role in regulating intracellular calcium signaling and is essential for immune cell functions. SOCE blockade with pyrazole derivative BTP2 has been explored as an anti-inflammatory strategy in preclinical models and Zegocractin (CM4620) is being investigated in Phase 2 clinical trials as an immunoregulatory agent. However, the mode of action a...

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Literature Corpus work: 3c0030c5-5c7c-5048-9f07-cc76f329d8ba
DOI: 10.1101/2025.04.28.651042

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