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Single-cell RNA-seq reveals the immune profile changes in patients with diarrhoeal-irritable bowel syndrome

31 May 2025

Abstract excerpt

BACKGROUND: Diarrhea-predominant irritable bowel syndrome (IBS-D) is characterized by recurrent abdominal pain and chronic diarrhea. T lymphocytes, which play a crucial role in gut inflammation and immune responses, may significantly contribute to the pathophysiology of IBS-D. However, the exact mechanisms by which T lymphocytes affect IBS-D remain unclear. The precise pathways and interactions involved in IBS-D...

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PMID: 40456298
DOI: 10.1016/j.bbadis.2025.167945

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