Article

Substantial Batch Effects in TCGA Exome Sequences Undermine Pan-Cancer Analysis of Germline Variants

2018-10-16

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> In recent years, research on cancer predisposition germline variants has emerged as a prominent field. The identity of somatic mutations is based on a reliable mapping of the patient germline variants. In addition, the statistics of germline variants frequencies in healthy individuals and cancer patients is the basis for seeking candidates for cancer predisposition genes. Th...

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Literature Corpus work: 3bfe116f-46ef-5c25-90bc-c329eeeb9867
DOI: 10.1101/445049

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