Impact of Variant-level Batch Effects on Identification of Genetic Risk Factors in Large Sequencing Studies

Abstract excerpt

<title>Abstract</title> <p>Background: Genetic studies have shifted to sequencing-based rare variants discovery after decades of success in identifying common disease variants by Genome-Wide Association Studies using Single Nucleotide Polymorphism chips. Sequencing-based studies require large sample sizes for statistical power but often inadvertently introduce batch effects because samples are typically collected...

Topics

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• Alzheimer Disease
• Apolipoproteins E
• Databases, Genetic
• Exome
• High-Throughput Nucleotide Sequencing
• Membrane Transport Proteins
• Mitochondrial Precursor Protein Import Complex Proteins
• Principal Component Analysis

Identifiers and source

Literature Corpus work

d6d1e8e1-3ef4-5d39-bc40-51dbfd84e4fc

DOI

10.21203/rs.3.rs-44710/v1