Article

Genome-wide association study in two cohorts from a multi-generational mouse advanced intercross line highlights the difficulty of replication

2018-08-08

Abstract excerpt

Replication is considered to be critical for genome-wide association studies ( GWAS ) in humans, but is not routinely performed in model organisms. We explored replication using an advanced intercross line ( AIL ) which is the simplest possible multigenerational intercross. We re-genotyped a previously published cohort of LG/J x SM/J AIL mice (F 34 ; n=428) using a denser marker set and also genotyped a novel c...

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Literature Corpus work: 3becae02-16d6-545d-a99a-d17665eb4f49
DOI: 10.1101/387613

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