Article

Heritability of Alzheimer-related plasma biomarkers in the Amish population

2025-05-14

Abstract excerpt

<h4>Structured Abstract</h4> <h4>INTRODUCTION</h4> Plasma biomarkers for Alzheimer disease (AD) hold promise for disease diagnosis and prediction, yet their genetic underpinnings remain underexplored. <h4>METHODS</h4> We measured plasma amyloid beta 40 (Aβ40), Aβ42, Aβ42/Aβ40, total tau (t-tau), phosphorylated tau 181 (p-tau181), Aβ42/t-tau, Aβ42/p-tau181, neurofilament light chain, and glial fibrillary acidic pro...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3bc81c78-7bf8-5ca5-b3b2-9e9448407ff8
DOI: 10.1101/2025.05.13.25327557

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Heritability of Alzheimer-related plasma biomarkers in the Amish populationDOI 10.1101/2025.05.13.25327557Read

Alzheimer Disease Plasma Biomarkers in the Mid-Western AmishSemantic proximity Read

Genetic architecture of Alzheimer’s disease-related plasma biomarkersSemantic proximity Read

The genetic architecture of Alzheimer disease risk in the Ohio and Indiana AmishSemantic proximity Read

Plasma amyloid β levels are driven by genetic variants near <i>APOE, BACE1, APP, PSEN2:</i> A genome-wide association study in over 12,000 non-demented participantsSemantic proximity Read

Generalizability of Tau and Amyloid Plasma Biomarkers in Alzheimer’s Disease Cohorts of Diverse Genetic AncestriesSemantic proximity Read

Polygenic Scores of Core-1 Alzheimer’s Disease Biomarkers Predict Early Cognitive and Pathological ChangeSemantic proximity Read

Genetic architecture of plasma Alzheimer disease biomarkersSemantic proximity Read

Biological variation estimates of Alzheimer’s disease plasma biomarkers in healthy individualsSemantic proximity Read

Interrogating the complex relationship between Alzheimer’s disease and blood pressure: two instrumental variable approaches to focus on pre-clinical stages of Alzheimer’s disease in UK BiobankSemantic proximity Read

Heritability of Alzheimer's disease plasma biomarkers: A nuclear twin family designSemantic proximity Read

Alzheimer’s disease susceptibility gene apolipoprotein e (<i>APOE</i>) and blood biomarkers in UK Biobank (N=395,769)Semantic proximity Read

The heritability of blood‐based biomarkers related to risk of Alzheimer's disease in a population‐based sample of early old‐age menSemantic proximity Read