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Heritability of Alzheimer's disease plasma biomarkers: A nuclear twin family design

26 Nov 2024

Abstract excerpt

INTRODUCTION: Alzheimer's disease (AD) is a highly heritable disease (60%-80%). Amyloid beta (Aβ) 42/40, neurofilament light chain (NfL), and glial fibrillary acidic protein (GFAP) are plasma biomarkers for AD. Clinical biomarker research would be served by an understanding of the sources of variance in these markers. METHODS: Blood concentrations of Aβ42/40, NfL, and GFAP of twins and their families (monozygotic...

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PMID: 39588748
DOI: 10.1002/alz.14269

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