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Article

G4Killer web application: a tool to design G-quadruplex mutations.

Bioinformatics (Oxford, England) - 1 May 2020

Brazda Vaclav, Kolomaznik Jan, Mergny Jean-Louis, Stastny Jiri

Abstract excerpt

MOTIVATION: G-quadruplexes (G4) are important regulatory non-B DNA structures with therapeutic potential. A tool for rational design of mutations leading to decreased propensity for G4 formation should be useful in studying G4 functions. Although tools exist for G4 prediction, no easily accessible tool for the rational design of G4 mutations has been available. RESULTS: We developed a web-based tool termed...

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Identifiers

PMID: 31985802
DOI: 10.1093/bioinformatics/btaa057
PMCID: PMC7214026

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