Article

Improved RAD51 binders through motif shuffling based on the modularity of BRC repeats

2020-05-15

Abstract excerpt

Exchanges of protein sequence modules support leaps in function unavailable through point mutations during evolution. Here we study the role of the two RAD51-interacting modules within the eight binding BRC repeats of BRCA2. We created 64 chimeric repeats by shuffling these modules and measured their binding to RAD51. We found that certain shuffled repeats were stronger than any of the natural repeats, suggesting...

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Literature Corpus work: 3b9c799b-7b30-55a5-bef4-7320e1031bdf
DOI: 10.1101/2020.05.14.097071

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