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Article

Design, synthesis, and characterization of BRC4 mutants based on the crystal structure of BRC4-RAD51(191-220).

Journal of molecular modeling - 1 Nov 2015

Zhao Dongxin, Lu Kui

Abstract excerpt

Breast cancer susceptibility gene 2 (BRCA2)-a human tumor suppressor gene-is related to various malignancies such as breast and ovarian cancer. This gene can induce the key protein RAD51 recombinase, which is involved in homologous recombination with single-stranded DNA in the human body and can regulate RAD51 to complete the repair of damaged double-stranded DNA. Eight highly conserved BRC repeat motifs in BRCA2...

Read the complete abstract on PubMed

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Share to Amino Acid Motifs
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Share to Chromatography, High Pressure Liquid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Structure, Tertiary

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Source

Identifiers

PMID: 26522863
DOI: 10.1007/s00894-015-2831-x

Genes

RAD51
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Design, synthesis, and characterization of BRC4 mutants based on the crystal structure of BRC4-RAD51(191-220).PMID 26522863Read ↗

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