Article

Nuclear eNOS interacts with and <i>S</i> -nitrosates ADAR1 to modulate type I interferon signaling and endothelial function

2024-05-25

Abstract excerpt

<h4>Background</h4> Nitric oxide (NO) generated by the endothelial NO synthase (eNOS) regulates vascular tone and endothelial homeostasis to counteract vascular inflammation. Most eNOS is localized at the cell membrane or in the Golgi apparatus, but the enzyme is also present in the endothelial cell nucleus. Here we assessed the relevance of nuclear eNOS and NO signaling for endothelial cell function. <h4>Methods...

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Literature Corpus work: 3b65951f-2844-5e26-9c91-047a3210a8bb
DOI: 10.1101/2024.05.24.595750

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