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Article

Cell cycle-regulated inactivation of endothelial NO synthase through NOSIP-dependent targeting to the cytoskeleton.

Molecular and cellular biology - 1 Sept 2005

Schleicher Michael, Brundin Fredrik, Gross Steffen, Müller-Esterl Werner, Oess Stefanie

Abstract excerpt

Nitric oxide (NO) plays a key role in vascular function, cell proliferation, and apoptosis. Proper subcellular localization of endothelial NO synthase (eNOS) is crucial for its activity; however, the role of eNOS trafficking for NO biosynthesis remains to be defined. Overexpression of NOS-interacting protein (NOSIP) induces translocation of eNOS from the plasma membrane to intracellular compartments, thereby...

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Source

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Identifiers

PMID: 16135813
DOI: 10.1128/MCB.25.18.8251-8258.2005
PMCID: PMC1234313

Genes

NOSIP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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