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Article

Smooth muscle expression of RNA editing enzyme ADAR1 controls activation of the RNA sensor MDA5 in atherosclerosis.

Nature cardiovascular research - 1 Oct 2025

Weldy Chad S, Li Qin, Monteiro João P, Peters Tim S, Guo Hongchao, Galls Drew, Gu Wenduo, Cheng Paul P, Ramste Markus, Li Daniel, Palmisano Brian T, Sharma Disha, Worssam Matthew D, Zhao Quanyi, Bhate Amruta, Kundu Ramendra K, Nguyen Trieu, Mokry Michal, Miller Clint L, van der Laan Sander W, Li Jin Billy, Quertermous Thomas

Abstract excerpt

Although genetic risk in coronary artery disease (CAD) is linked to changes in gene expression, recent discoveries have revealed a major role for A-to-I RNA editing in CAD. ADAR1 edits immunogenic double-stranded RNA (dsRNA), preventing activation of the dsRNA sensor MDA5 (IFIH1) and downstream interferon-stimulated gene signaling. Using human plaque analysis and human coronary artery smooth muscle cells (SMCs),...

Read the complete abstract on PubMed

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Share to Adenosine Deaminase
Share to Coronary Vessels

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Interferon-Induced Helicase, IFIH1

Share to Muscle, Smooth, Vascular

Share to Myocytes, Smooth Muscle

Share to Plaque, Atherosclerotic

Share to RNA Editing

Share to Vascular Calcification

Source

Open in PubMed Open full text

Identifiers

PMID: 40958051
DOI: 10.1038/s44161-025-00710-5
PMCID: PMC12520979

Genes

CAD
IFIH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Smooth muscle expression of RNA editing enzyme ADAR1 controls activation of the RNA sensor MDA5 in atherosclerosis.PMID 40958051Read ↗

Smooth muscle expression of RNA editing enzyme <i>ADAR1</i> controls activation of RNA sensor MDA5 in atherosclerosisSemantic proximity Read ↗

Adenosine-to-Inosine (A-to-I) RNA Editing by ADAR1 to Control RNA Sensing in Cardiovascular Disease.Semantic proximity Read ↗

Increased A-to-I RNA editing in atherosclerosis and cardiomyopathiesSemantic proximity Read ↗

RNA editing underlies genetic risk of common inflammatory diseases.Semantic proximity Read ↗

ADAR regulates APOL1 via A-to-I RNA editing by inhibition of MDA5 activation in a paradoxical biological circuitSemantic proximity Read ↗

Protein recoding by ADAR1-mediated RNA editing is not essential for normal development and homeostasis.Semantic proximity Read ↗

ADAR1 haploinsufficiency and sustained viral RdRp dsRNA synthesis synergize to dysregulate RNA editing and cause multi-system interferonopathySemantic proximity Read ↗

Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature.Semantic proximity Read ↗

Cross-species single-cell RNA sequencing reveals divergent phenotypes and activation states of adaptive immunity in human carotid and experimental murine atherosclerosis.Semantic proximity Read ↗

RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself.Semantic proximity Read ↗

The majority of A-to-I RNA editing is not required for mammalian homeostasisSemantic proximity Read ↗

ADAR1-Mediated RNA Editing, A Novel Mechanism Controlling Phenotypic Modulation of Vascular Smooth Muscle Cells.Semantic proximity Read ↗

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