Article

The TAS1R2 sweet taste receptor regulates skeletal muscle mass and fitness

2023-02-09

Abstract excerpt

<title>Abstract</title> <p>Muscle fitness and mass deteriorate under the conditions of obesity and aging for reasons yet to be fully elucidated. Herein, we describe a novel pathway linking peripheral nutrient sensing and skeletal muscle function through the sweet taste receptor TAS1R2 and the involvement of ERK2-PARP1-NAD signaling axis. Muscle-specific deletion of TAS1R2 (mKO) in mice produced elevated NAD level...

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Literature Corpus work: 3b5cfed4-6d93-5417-8c40-6f39efffe92e
DOI: 10.21203/rs.3.rs-2475555/v1

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