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Article

VPS39-deficiency observed in type 2 diabetes impairs muscle stem cell differentiation via altered autophagy and epigenetics

23 Apr 2021

Abstract excerpt

Abstract Insulin resistance and lower muscle quality (strength divided by mass) are hallmarks of type 2 diabetes (T2D). Here, we explore whether alterations in muscle stem cells (myoblasts) from individuals with T2D contribute to these phenotypes. We identify VPS39 as an important regulator of myoblast differentiation and muscle glucose uptake, andVPS39is downregulated in myoblasts and myotubes from individuals...

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Share to Autophagy in Disease and Therapy
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PMID: 33893273
DOI: 10.1038/s41467-021-22068-5

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