Article

Inhibition of Microglia Over-activation Restores Neuronal Survival in a Mouse Model of CDKL5 Deficiency Disorder

2021-02-17

Abstract excerpt

<title>Abstract</title> <p>BackgroundCDKL5 Deficiency Disorder (CDD), a severe neurodevelopmental disorder characterized by early-onset epilepsy, intellectual disability, and autistic features, is caused by mutations in the <italic>CDKL5</italic> gene. Evidence in animal models of CDD showed that absence of CDKL5 negatively affects neuronal survival, as well as neuronal maturation and dendritic outgrowth; however...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 67136079-e1d3-50dc-9ef2-79f53fc58eda
DOI: 10.21203/rs.3.rs-203260/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Inhibition of Microglia Over-activation Restores Neuronal Survival in a Mouse Model of CDKL5 Deficiency DisorderDOI 10.21203/rs.3.rs-203260/v1Read

Probing the functions of microglial cyclin-dependent kinase 5 under physiological and pathological conditionsSemantic proximity Read

Multi-Site Investigation of Gut Microbiota in CDKL5 Deficiency Disorder Mouse Models: Targeting Dysbiosis to Improve Neurological OutcomesSemantic proximity Read

Voluntary Running Improves Behavioral and Structural Abnormalities in a Mouse Model of CDKL5 Deficiency DisorderSemantic proximity Read

Mosaic CDKL5 expression in heterozygous female mice is associated with age- and region- dependent remodeling of inhibitory circuitsSemantic proximity Read

Astroglial Dysfunction in Models of CDKL5 Deficiency DisorderSemantic proximity Read

CDKL5 deficiency predisposes neurons to cell death through the deregulation of SMAD3 signalingSemantic proximity Read

Effects of a ciliary neurotrophic factor (CNTF) small-molecule peptide mimetic in an in vitro and in vivo model of CDKL5 deficiency disorderSemantic proximity Read

Inhibition of GSK3β rescues hippocampal development and learning in a mouse model of CDKL5 disorderSemantic proximity Read

Treatment with the GSK 3‐beta inhibitor Tideglusib improves hippocampal development and memory performance in juvenile, but not adult, Cdkl5 knockout miceSemantic proximity Read

Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiologySemantic proximity Read

The Role of Microglia in Neurodevelopmental Disorders and their TherapeuticsSemantic proximity Read

mGluR5 PAMs rescue cortical and behavioural defects in a mouse model of CDKL5 deficiency disorderSemantic proximity Read