Article

Depleting trafficking regulator CASK promotes intercalated disc organization and ventricular function

2024-10-17

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> The intercalated disc (ID) electromechanically couples adjacent cardiomyocytes. Alteration of this structure plays a central role in cardiac arrhythmias, notably arrhythmogenic cardiomyopathy (ACM), an inherited genetic disorder of desmosomes. Calcium/Calmodulin-Dependent Serine Protein Kinase (CASK), a costameric component of the lateral membrane, regulates cardiomyocyte pr...

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Literature Corpus work: 3b2fc6e1-538e-586e-a6e3-464860c26725
DOI: 10.1101/2024.10.14.618172

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