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Article

Disturbed Desmoglein-2 in the intercalated disc of pediatric patients with dilated cardiomyopathy.

Human pathology - 1 Sept 2017

Kessler Elise L, Nikkels Peter Gj, van Veen Toon Ab

Abstract excerpt

Dilated cardiomyopathy (DCM) leads to disturbed contraction and force transduction, and is associated with substantial mortality in all age groups. Involvement of a disrupted composition of the intercalated disc (ID) has been reported. However, in children, little is established about such subcellular changes during disease, because of the pathological mix-up with the ongoing cardiac maturation. This leaves...

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PMID: 28764973
DOI: 10.1016/j.humpath.2017.07.012

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