Article
Intercalated disc abnormalities, reduced Na(+) current density, and conduction slowing in desmoglein-2 mutant mice prior to cardiomyopathic changes.
Cardiovascular research - 1 Sept 2012
Rizzo Stefania, Lodder Elisabeth M, Verkerk Arie O, Wolswinkel Rianne, Beekman Leander, Pilichou Kalliopi, Basso Cristina, Remme Carol Ann, Thiene Gaetano, Bezzina Connie R
Abstract excerpt
AIMS: Mutations in genes encoding desmosomal proteins have been implicated in the pathogenesis of arrhythmogenic right ventricular cardiomyopathy (ARVC). However, the consequences of these mutations in early disease stages are unknown. We investigated whether mutation-induced intercalated disc remodelling impacts on electrophysiological properties before the onset of cell death and replacement fibrosis. METHODS...
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