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Article

Refining the molecular organization of the cardiac intercalated disc.

Cardiovascular research - 1 Mar 2017

Vermij Sarah H, Abriel Hugues, van Veen Toon A B

Abstract excerpt

This review presents an extensively integrated model of the cardiac intercalated disc (ID), a highly orchestrated structure that connects adjacent cardiomyocytes. Classically, three main structures are distinguished: gap junctions (GJs) metabolically and electrically connect cytoplasm of adjacent cardiomyocytes; adherens junctions (AJs) connect the actin cytoskeleton of adjacent cells; and desmosomes function as...

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Identifiers

PMID: 28069669
DOI: 10.1093/cvr/cvw259

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