Article

A systems genomics approach to uncover patient-specific pathogenic pathways and proteins in a complex disease

2019-07-04

Abstract excerpt

We describe a novel precision medicine workflow, the integrated single nucleotide polymorphism network platform (iSNP), designed to identify the exact mechanisms of how SNPs affect cellular regulatory networks, and how SNP co-occurrences contribute to disease pathogenesis in ulcerative colitis (UC). Using SNP profiles of 377 UC patients, we mapped the regulatory effects of the SNPs to a human signalling network co...

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Literature Corpus work: 3b23dcaf-33f4-58d9-827a-73aaeb83fa72
DOI: 10.1101/692269

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