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Article

Enabling Precision Medicine through Integrative Network Models.

Journal of molecular biology - 14 Sept 2018

Yao Victoria, Wong Aaron K, Troyanskaya Olga G

Abstract excerpt

A key challenge in precision medicine lies in understanding molecular-level underpinnings of complex human disease. Biological networks in multicellular organisms can generate hypotheses about disease genes, pathways, and their behavior in disease-related tissues. Diverse functional genomic data, including expression, protein-protein interaction, and relevant sequence and literature information, can be utilized...

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Identifiers

PMID: 30003887
DOI: 10.1016/j.jmb.2018.07.004
PMCID: PMC13037550

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