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Article

Decoding non-coding SNPs: systems genomics modelling dissects the heterogeneity of IBD.

Molecular systems biology - 1 Feb 2026

Módos Dezső, Thomas John P, Brooks-Warburton Johanne, Poletti Martina, Bohar Balazs, Liu Yufan, Madgwick Matthew, Csabai Luca, Kang Wen-Xin, Alexander-Dann Benjamin, Zoufir Azedine, Sudhakar Padhmanand, Cozzetto Domenico, Fazekas David, Samarajiwa Shamith, Carding Simon R, Powell Nicholas, Verstockt Bram, Bender Andreas, Korcsmaros Tamas

Abstract excerpt

Genome-wide association studies have identified numerous susceptibility loci in complex diseases, such as chronic immune-mediated inflammatory disorders (IMIDs), yet their impact on pathomechanisms remains poorly understood. Low effect sizes, polygenicity, and predominance within non-coding genomic regions remain major challenges to the functional interpretation of IMID-associated single-nucleotide polymorphisms...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41299027
DOI: 10.1038/s44320-025-00169-3
PMCID: PMC12864814

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